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The more well known and researched ones are: [2] HLA-DR3, associated with thyroid gland atrophy HLA-DR5, associated with an enlarged thyroid gland These immune regulatory genes are closely associated with the autoimmune process of Hashimotos

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A healthy gut microbiota as required for optimal homeostasis places the gut mucosal immune system in a difficult position as it must tolerate beneficial commensals while preventing pathogen overgrowth