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Interestingly, a few cases of differential metabolic changes (ie, fold change of MTX treatment over basal levels) were associated with MTX resistance (at 96 hours)

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Assessment of antioxidant capacity in vitro and in vivo

At this moment, although regulatory clarity on postbiotics is developing, because they are chemically defined metabolites rather than live organisms, they are likely to follow a pathway similar to that of small molecule active pharmaceutical ingredients, which involves rigorous impurity profiling, stability, dose-range toxicology, and local tolerability studies, among other considerations