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Investigations of the Connectivity Map and high-throughput transcriptional profiling suggested that GHK (and by extension GHK-Cu) may up- or down-regulate thousands of genes, many of which are associated with tissue regeneration, extracellular matrix biology, inflammation, and oxidative stress response

The Precision Peptide Genetic Test examines key variants in genes such as FTO and MC4R that influence metabolic and tissue-health pathways

Apart a clinical study carried out in the late sixties, most data are available starting from the eighties

This methodological heterogeneity mirrors the variability observed in human studies