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Presence of GSH or NAC reduces oligomerization of secreted L68Q-hCC at 24, 48, and 72 h To investigate whether NAC or GSH reduces the oligomerization of secreted L68Q-hCC in a cellular system, we treated cells expressing WT or L68Q-hCC with both agents

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Significant brain alterations in pain-processing areas, abnormal pain modulation, central sensitization, cortical hyperexcitability, neurogenic inflammation, and ongoing neuroinflammation are central to the development and persistence of chronic migraines (35)

The simultaneous counteraction of these two NO-mediated opposite effects in vivo has never been addressed