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A recent study reported that the novel mitophagy inducer miriplatin-loaded liposomes (LMPt) enhance LONP1 binding to polymerase gamma (POLG) and TFAM, thereby resulting in POLG and TFAM degradation, which inhibits mtDNA replication and suppresses pancreatic cancer cell proliferation [160]
These abnormalities may be due to both acquired and genetic factor ,
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Therefore, most data are rather descriptive based on knockout, inhibition, or overexpression of redoxins and subsequent measurement of lipid peroxidation and/or rescue by ferroptosis inhibitors/inducers
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