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The N-hexanoic (C-terminal) and 6-aminohexanoic amide (N-terminal) modifications introduced during the lead-optimization phase of the Harding laboratorys Ang IV-analog program were specifically designed to increase hydrophobicity, decrease hydrogen bonding, and improve metabolic stability against the proteases that degrade native angiotensin IV

Initial gains may come quickly as inflammation decreases and blood flow improves, but the deeper tissue remodeling required for lasting resolution takes longer

L.OttavianiM.AlbanesiV.VidolinA

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