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As our scientific understanding advances, we suspect that we will gain greater understanding of how the ever-changing nature of the disease process requires different combinations of therapeutic interventions, with these treatment modalities tracking changes in the substrate and pathophysiological mechanisms of the disease in an iterative manner

Molecular and transcriptomic studies have also provided deeper insights into the mechanisms regulating resistance, allowing the development of specific inhibitors targeting TCSs or LPS modification pathways, which are promising therapeutic targets

To view or add a comment, sign in Visualizing the Problem of PEEP, and the Promise of Balance With mechanical ventilation, too little PEEP allows alveoli to collapse and reopen (derecruitment injury)

EFFECTS ON MAN 9.1