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305 The probiotic Lactobacillus reuteri (Lr) within melanoma promotes the local generation of IFN by CD8 + T cells through the release of its tryptophan breakdown metabolite, indole-3-aldehyde (I3A), thus enhancing ICI efficacy

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Aromatase is an enzyme that converts other hormones, such as androstenedione and testosterone, into estrogen (Verma 2009

It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose