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The fourth line of defense is the adaptation (cellular signalling antioxidant defense) system

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

It may indicate the increased SELENOP transport across the neural barriers, due to high expression of LRP8 at the BBB, which keeps Se levels relatively stable, even during deficiency periods making an adequate Se pool available in the CNS (Zachara et al., 2001)