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Pentosan polysulfate has been associated with pigmentary maculopathy, which diminishes visual capacity.9 There has not been enough research to fully support the link between an abnormal immune response in patients with interstitial cystitis and the side effects linked to use of pentosan polysulfate.10 Dimethyl sulfoxide reduces pain and inflammation associated with interstitial cystitis

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Sorrenti V, Di Giacomo C, Acquaviva R, Barbagallo I, Bognanno M, Galvano F