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Current clinical useparticularly within sports medicine and regenerative medicine practicesis largely based on case reports, anecdotal experience, and mechanistic rationale rather than large-scale randomized controlled trials

This should be the primary choice when repair matters more than wrinkle correction

Promotes healthy weight management and improved metabolic function

By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide