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Sphingolipids, which can be divided into three different structural categories, i.e., sphingoid bases and derivatives, ceramides, and complex sphingolipids ( In this review, we will mainly discuss [i] the alterations in sphingolipid metabolism possibly involved in MASLD pathogenesis, with particular emphasis on those related to its progression to MASH, and [ii] the impact of current and potentially novel therapies that target sphingolipid metabolism for MASH treatment

Its primary mechanism involves restoring the activity of key mitochondrial enzymes, such as SOD1, CCS, and CCO, thereby re-establishing metabolic function [51]