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To determine which would be the focus of this study, through immunoblotting and quantitative real-time PCR, the expression profiles of seven different classes of GSTs were explored at both the transcription and protein levels for 13 miscellaneous human cancer cell lines consisting of A549 (lung), MCF7 and MDA-MB-231 (breast), PANC-1, MIA Paca-2 and SW1990 (pancreas), M7609, COLO320HSR, SW480 and HCT116 (colon), HepG2 (liver), HT1080 (fibrosarcoma), and HeLa (cervical) were explored

Given the FoxO1 ablation induced -cell dedifferentiation and caused hyperglycemia under physiologic stress 22 , we determined whether LOsG/ROS stresses decrease FoxO1 expression and thus induce -cell dedifferentiation

Curcumin Curcumin, chemically identified as 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is the principal bioactive component derived from the rhizome of Curcuma longa L