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The rHrGSTm1 labeled with histidine (His) was purified by passage through an Ni column and eluted through an imidazole gradient of 20500 mM

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Sulfonylureas stimulate insulin secretion by closing ATP-sensitive potassium channels in pancreatic cells, while thiazolidinediones activate peroxisome proliferator-activated receptor-gamma (PPAR-) to improve insulin sensitivity

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