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This N-terminal insertion drives conformational changes in the TMD, including the outward movement of transmembrane helix 6 (TM6) and reorganization of TM5 and TM7, that create a binding surface for heterotrimeric G proteins on the intracellular face of the receptor

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The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and 3-AR knock-out mice