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However, some studies showed no association between MTHFR and MDD or antidepressant treatment response 74,75

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So there still needs to be a lot of hashing out what the criteria are, and so I do think it's important that we get more research in this area, but I think one of the

Kundu D, Roy A, Mandal T, et al

Current research is constrained by methodological limitations, including small sample sizes, inadequate control of confounding variables, and substantial heterogeneity in outcome measures, which collectively compromise the reliability and generalizability of findings