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Even if you are overweight, you can be malnourished in terms of micronutrients a phenomenon sometimes called hidden hunger. In fact, people with obesity are often already at risk of vitamin and mineral deficiencies due to poor diet quality

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Lead series optimization Our goal was to enhance interactions of the small-molecule agonists with the GLP-1R through lowering the energy barrier to achieve the receptor-bound agonist conformation, and by adjusting polar substituents, with minimal increases in molecular weight