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ROS cause direct damage to lipids, proteins, and nucleic acids, while also activating NF-kB-dependent inflammatory gene expression

There is an urgent need for validated treatments for long COVID, says Julia Moore Vogel, co-principal investigator of LoCITT

Nicotinamide and EGCG reduce A accumulation and protein oxidation in aged 3xTg-AD hippocampal neurons Since intracellular A aggregates increase across the lifespan of the 3xTg-AD model in vivo [38], and in vitro [1] and a hallmark for brain aging and the progression of AD is protein oxidation, including tyrosine nitration [1, 39], we immunostained neurons for A accumulation and protein nitration and evaluated the effects of treatment with nicotinamide and EGCG

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