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As mentioned above, different NSAIDs carry different risks of either gastrointestinal or cardiovascular toxicity

Mantovani G, Isidori AM, Moretti C, Di Dato C, Greco E, Ciolli P et al (2019) Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the SERENA study, a randomized, double-blind, placebo-controlled trial

With severe syndromes, such as vascular and multiorgan failure following major vessel occlusion or similar noxious procedures [66,71,72,73,74,75,76,77,78,79,80,81,82], the particular activation of the collateral pathways (i.e., azygos vein direct blood delivery) might be essential to counteract severe central and peripheral lesions, intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension