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Appetite changes are less consistently reported with AOD-9604 than with semaglutide and in controlled studies, most short-term safety signals mirrored placebo rates

Autoimmune predisposition in Down syndrome may result from a partial central tolerance failure due to insufficient intrathymic expression of AIRE and peripheral antigens

In established tumors, TAMs can further promote immunosuppression and tumor progression by producing pro-angiogenic factors, such as VEGF, and by releasing IL-10-rich signals that impair effective cytotoxic T-cell responses (126)