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Standardized behavior assessment tools play a crucial role

compares the vitamin D metabolism genes and VDR CpG island methylation in the genomic DNA of livers from HFD-fed mice with those of controls

J Pharmacokinet Pharmacodyn 42:463475 Duca FA, Ct CD, Rasmussen BA et al (2015) Metformin activates a duodenal AMPK-dependent pathway to lower hepatic glucose production in rats