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Risk of Legal Blindness and Ischemic Optic Neuropathy The GLP-1 cohort had a statistically significant reduction in risk of legal blindness, at all measured time periods, as compared to the control, with a 1-year hazard ratio of 0.589 (95% CI: 0.4760.728), 3-year HR of 0.677 (95% CI: 0.5830.788), and 5-year HR of 0.669 (95% CI: 0.5830.768)

23 In December 1987, Stephen Blooms team confirmed in a Lancet paper that GLP-1(7-36) is a human intestinal hormone that stimulates insulin production in the pancreas and lowers blood sugar

J Neurosci 27 : 17561768

The post raises heart rate elevation, blood pressure increases, and potential arrhythmia risk as the theoretical concerns when a stimulant is layered onto GLP-1 therapy