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"The Corticohippocampal Circuit, Synaptic Plasticity, and Memory"

Unlike core peptides, KPV's effects are not mediated through MC-Rs, suggesting alternative pathways such as IL-1 inhibition

The mutual outcome of these two effects is the upregulation of hepatic BA formation and emission of conjugated BAs into the blood circulation, which distally anchors the FXR in the bone marrow, resulting in the loss of osteoblast function, negatively impacting BMD, bone volume fraction, and fracture resistance (115)

Linda Burghardt, a researcher in Great Neck, New York, started taking Wegovy because her doctor thought it might reduce arthritis pain in her knees and hips