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b , c , Normalized 4-hour ( b ) SD and ( c ) HFD consumption post-injection of vehicle or danuglipron in mGlp1r, full-length human GLP1R (hGLP1R) or mGlp1r-S33W (S33W) expressing mice mGLP1R n = 8, hGLP1R n = 9, mGLP1R S33W n = 4, two-way ANOVA with Bonferroni correction)

When prescribed, clinicians typically consider: BMI requirements: Adults with obesity (typically BMI of 30 or higher), or overweight (BMI of 27 or higher) with at least one weight-related health condition like high blood pressure, type 2 diabetes, or high cholesterol Medical evaluation: A clinician reviews your complete health history before prescribing Certain medical conditions may make oral semaglutide inappropriate

Lai JT, Liu CL, Liu TC