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During childhood, concentrations of tHcy in plasma were largely stable (mean 58 mol/l) under treatment with OHCbl 1 mg IM every other week given by the local pediatrician

Preclinical and clinical data suggest that FXR and PPAR dual modulators can improve insulin sensitivity, reduce hepatic steatosis, and attenuate fibrosis, which may complement the actions of GLP-1/GIP/GCG receptors agonists

4 A 2025 systematic review examining GLP-1 receptor agonists for depression found that several observational studies showed reduced depressive symptoms in people taking these medications, though results from randomised controlled trials were more mixed