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We reiterate below one comment especially relevant to the calculation of burden discussed in this section

Check whether the product was shipped on ice or cold packs (indicating cold chain maintenance) and whether the label specifies refrigeration requirements

Nature 429 : 184187

A 2011 systematic review and meta-analysis of nine randomized controlled trials including 19,810 women reported that combined supplementation with vitamins C (1,000 mg/day) and E (400 International Units/day) during pregnancy does not reduce the risk of preeclampsia in women with either low/moderate risk or high risk for this disorder (90)