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It's a deep dive into biochemistry, cellular signaling, and the intricate dance of systemic versus localized effects

What they found: Significant improvement in muscle insulin signaling (AKT/mTOR pathway) Increased expression of genes for mitochondrial biogenesis Increased expression of tissue remodeling Drop in HOMA-IR of ~25 % No adverse events Why it matters: This was the first high-quality randomized clinical trial of NMN in humans

In the context of a heightened inflammatory milieu generated by HFD, KLF9 normally expressed in endometrial fragments may promote the production of pro-inflammatory genes that hinder tissue implantation into the peritoneum

[DOI] [PubMed] [Google Scholar] 93.James SJ, Melnyk S, Jernigan S, et al