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56 Similarly, landing from a jump, especially with improper technique or insufficient muscle strength, can result in significant anterior tibial translation and internal rotation, both of which are detrimental to the integrity of the ACL

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These preclinical studies in a -thalassemic mouse model generated the rationale for a phase II proof-of-concept study (ClinicalTrials.gov NCT03692052) of mitapivat in patients with nontransfusion-dependent thalassemias (NTDTs), including both - and -thalassemia genotypes

Abstract Virus-induced cell death has long been thought of as a double-edged sword in the inhibition or exacerbation of viral infections