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In recent years, several main relevant mechanisms of the novel antidiabetic drugs in preclinical model of diabetic HFpEF were investigated (Table 5)

Indeed, the C677T mutation of the MTHFR gene is not unequivocally associated with increased cardiovascular risk

Conflict of interest: ZW, BSL, and SLH are named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics, and have the right to receive royalty payment for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland HeartLab, Quest Diagnostics, and Procter & Gamble

Hepatology 60(2):715735