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The most robust evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), in which retatrutide was evaluated over 48 weeks in adults with obesity but without type 2 diabetes

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In preclinical and clinical studies, Retatrutyd Triple G is being evaluated in the context of incretin signalling, glucose homeostasis, glucose-dependent insulinotropic response, lipid metabolism and the regulation of energy balance

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