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2 Establishes GLP-1RAs are engineered to overcome the rapid degradation of native GLP-1 through DPP-4resistant modifications and exposure-extending strategies such as fatty-acid acylation, enabling sustained receptor occupancy

Zepbound (tirzepatide): It is the newest FDA-approved once-weekly subcutaneous injectable medication that works also as a glucose-dependent insulinotropic peptide (GIP) receptor agonist along with GLP-1 receptor agonist

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Heber U., Miyake C., Mano J., Ohno C., Asada K