For example, integrin v 3 is highly expressed in the BBB, but its typical ligand, the RGD peptide, cannot effectively mediate BBB penetration for brain-targeted delivery
In addition, although PSM was performed for available characteristics, several confounding variables exist that cannot be accounted for based on available data, including lifestyle factors, such as diet and physical activity, and other clinical characteristics, such as severity of chronic pancreatitis and genetic predisposition/family history of pancreatic cancer
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Future comprehensive studies are required to clarify irons involvement in various types and stages of malignancies
