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Encourage them to move on to the recommended therapeutic dose for weight loss

Lancet (2014) 384:134957

10.1016/j.npep.2008.02.001 23 BryantN

Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit