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Cortisol, glucose, and other markers have natural diurnal variation, and early morning values provide the most standardized comparison between draws

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3,507 GLP-1RAs reduce liver fat accumulation by activating AMPK, which inhibits fatty acid synthesis enzymes and promotes fatty acid -oxidation, thus diminishing lipid droplet accumulation in hepatocytes

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Deeper tone changes and smoother texture may appear over 12 to 16 weeks, especially if sun protection and lifestyle are also under control

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However, the most effective approach is not choosing one over the other, but understanding how they work together

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