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doi: 10.1146/annurev-immunol-032713-120236 65 PareGVitryJMerchantMLVaillancourtMMurruAShenYet al

Disruption of metal transport proteins can lead to both toxic accumulation and essential deficiencies (Zheng and Monnot, 2012).Chelation therapies and metal modulating nutraceuticals are currently under investigation as potential therapeutic options in AD (Sensi et al., 2018)

This can be achieved using antiangiogenic agents which promote vascular normalization [28, 29]

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