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its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust ( Finally, insurmountable technical barrierssuch as inability to manufacture stable formulations, extreme immunogenicity, or lack of feasible delivery routesmay justify abandonment independent of biological plausibility

Side Effects of Rosacea BOTOX Treatment Common side effects of intradermal botulinum toxin injections are mild pain and bruising at the injection site, which is usually tolerable and resolves spontaneously

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