The mechanisms by which metformin exerts anorexigenic effects are still emerging, with evidence of direct and indirect effects on the gastrointestinal tract, the gut microbiome, the CNS, and the gut-brain axis ( Metformin health gains versus weight loss The primary rationale for delayed introduction of metformin within AIWG treatment guidelines is limited efficacy in reversing the typically significant burden of weight gain induced by antipsychotic treatment
Eye (lond) 28:521537 Zakharov S, Pelclova D, Urban P, Navratil T, Diblik P, Kuthan P, Hubacek JA, Miovsky M, Klempir J, Vaneckova M, Seidl Z, Pilin A, Fenclova Z, Petrik V, Kotikova K, Nurieva O, Ridzon P, Rulisek J, Komarc M, Hovda KE (2014) Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features
Week one brings better sleep quality
This is largely due to their FDA-approved indications for use in T2DM and obesity only