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Hypoxia contributes to vascular changes such as increased stiffness, tortuosity, and decreased vascular perfusion

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NSAID-Induced Gut Damage: A Specific Research Context Non-steroidal anti-inflammatory drugs (NSAIDs) cause significant gastrointestinal damage through prostaglandin synthesis inhibition prostaglandins are critical for mucosal maintenance, and their suppression leads to reduced mucus production, decreased bicarbonate secretion, and impaired mucosal blood flow