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Davies said weight loss of up to 5% can improve hyperglycemia and hypertension, 5% to 10% weight loss can prevent type 2 diabetes and improve polycystic ovary syndrome and dyslipidemia, 10% to 15% weight loss can lead to improvements in cardiovascular disease and 15% or greater weight loss may induce type 2 diabetes remission and lower risks for CV mortality and heart failure with preserved ejection fraction

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Always follow the manufacturer's recommended titration schedule in the SmPC, and consider extending the time at lower doses if patients experience significant gastrointestinal symptoms