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The other main roles of arhalofenate are to activate AMPK, inhibit NF-B and NLRP3 inflammasomes to promote the polarisation of anti-inflammatory macrophages, as well as significantly reduce UA-induced inflammation (Salminen et al., 2011

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[DOI] [PubMed] [Google Scholar] 97.Microglial activation of GLP-1R signaling in neuropathic pain promotes gene expression adaption involved in inflammatory responses