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In some embodiments, a formulation described herein, further comprises a gelling agent (e.g., poloxamer 407) and provides release of the therapeutic agent over a period of from about 1 day to about 3 days

The organoids presented with liver-like functional features, which included the production of serum proteins and coagulation factors and supported ureagenesis

This pathway also provides NADH, which is important as a cofactor of methemoglobin reductase to regenerate oxidized Hb to its reduced functional state

Untreated B12 deficiency causes peripheral neuropathy (tingling, numbness, balance issues) and, in severe cases, cognitive decline