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Targeting the Gut-Brain-Ferroptosis Axis: Molecular Mechanisms and Therapeutic Potential in Alzheimers Disease and Epilepsy

Even individuals who are medically healthy may feel that their bodies are somehow insufficient." And today, social media has further magnified those pressures and narratives

H-Gln(Trt)-Ala-Ala-Lys(C18diacidmono-t-butyl-Glu-AEEA-AEEA)-OtBu)-Glu(OtBu)- Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(Pbf)-Gly-Arg(Pbf)-Gly-OtBu H-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(C18diacidmono-t-butyl-Glu-AEEA-AEEA)-OtBul)- Glu (OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(pbf)-Gly-Arg (pbf)-Gly-OtBu Boc-His(Trt)-Aib-Glu(OtBu)-Gly-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp (OtBu)-Val-Ser(Oxa)-Ser(tBu)-Tyr(tBu)-Leu- Glu(OtBu)-Gly-Gln(Trt)-Ala-Ala-Lys(C18diacid-Glu-AEEA-AEEA)-Glu (OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val-Arg(pbf)- Gly-Arg (pbf)-Gly-OtBu (Protected Semaglutide) (Crude Semaglutide) Pure Semaglutide Scheme-II The present invention provides a hybrid approach for the preparation of Semaglutide compound of formula-I