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GPx isoenzymes are all antioxidant enzymes that reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione (Figure 2a )

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Glutathione: Pharmacological aspects and implications for clinical use in non-alcoholic fatty liver disease

Within the GHSR1a-MC3R dimer, the GHSR1a inverse agonist SP-analog eliminates amplification of MC3R signaling (Rediger et al., 2011), an effect likely due to the dependence on GHSR1a constitutive activity