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Conclusion: GLP-1 RAs significantly improve key biomarkers of systemic inflammation (CRP, TNF-) in patients with T2D compared to various active comparators and placebo

During the first 2 to 4 weeks, you may experience: Nausea : Often most pronounced after meals, typically improving over time Reduced appetite : You may feel full more quickly and have less interest in food Mild abdominal discomfort : Bloating or a feeling of fullness Altered bowel habits : Either constipation or loose stools Fatigue : Some patients report tiredness as their body adjusts These effects are generally mild to moderate and tend to diminish as your body adapts to the medication

According to the American Diabetes Association (ADA) Standards of Care, GLP-1 receptor agonists with proven cardiovascular benefit are recommended for many patients with type 2 diabetes who have established cardiovascular disease, with individualized therapy based on patient factors