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instead they are a precaution stemming from findings in the Saxenda (liraglutide) trials where a small number of participants reported psychiatric symptoms (though these were not significantly different from the placebo group)

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BTZ treatment upregulates PK2 and the epigenetic regulatory enzyme KDM6A in the PNS and spinal cord, inducing mechanical pain (Moschetti et al., 2019

The FDA-approved, branded versions of GLP-1 products were so popular that the brand manufacturers were not able to keep up with demand, prompting the FDA to declare a shortage for each of the semaglutide and tirzepatide products over the course of 2022