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This decision was made because this review aims to provide a general overview of the current literature landscape and summarize the progress of research in this emerging area, rather than to conduct a formal meta-analysis or systematic review

Evidence from Cardiovascular Outcome Trials (CVOTs) Multiple landmark clinical trials have firmly established the cardiovascular protective effects of GLP-1 receptor agonists (GLP-1 RAs), fundamentally altering treatment paradigms beyond diabetes management alone

The delayed gastric emptying caused by GLP-1/GIP agonists may theoretically affect the absorption of other medications, though significant clinical impacts with sertraline have not been established

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