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This toolkit facilitated the categorisation of clinical recommendations according to their evidence strength, ensuring that all therapeutic applications discussed in this review are grounded in a clear, evidence-based rationale

Psychiatry 48, 186195

The current evidence base is heavily skewed towards preclinical studies, and while these provide a strong foundation, they cannot definitively predict human outcomes

On the other hand, several GPs that had no significant fold change at the end of 4th week during 4-week intermittent fasting compared with the levels before 4-week intermittent fasting, had a significant fold change 1 week after 4-week intermittent fasting compared with the levels at the end of 4th week during 4-week intermittent fasting (e.g., PRKCSH, HIST1H2BA) (Table 2)