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Jame-Chenarboo, F., Ng, H

Codon-optimized genes encoding 3-HSDH and 3-HSDH were integrated into Bacteroides thetaiotaomicron , allowing the conversion of DCA to isoDCA, which promotes colonic pTreg cell differentiation and maintains mucosal immune tolerance ( Bacteroides uniformis in a DSS-induced colitis mouse model shifted the microbiota composition by promoting beneficial genera, such as Bacteroides and Bifidobacterium , and decreasing potential pathogens

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