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This positive outcome can be partially ascribed to the activity of one of its active constituents, 20-hydroxyecdysone, which regulates various molecular signaling networks

Steullet, et al., Neuroscience

For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]