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Rare occurrences of pancreatitis or gallbladder issues can be minimized with careful screening and ongoing monitoring

13.8%: Broad eligibility + perfect adherence 10.4%: Broad eligibility + real-world adherence 8.1%: Narrow eligibility + perfect adherence 6.1%: Narrow eligibility + real-world adherence Even with cost-sharing (e.g., $90 copay), premium increases only drop by 12 percentage points

This classification reflects the mechanistic heterogeneity of conditions in which BCAA metabolism is implicated, rather than implying a uniform inflammatory etiology

Once released, this hormone stimulates the pancreas to secrete insulin, which enables cells to absorb glucose from the blood